Mefenamic acid inhibits the activity of the enzymes cyclooxygenase i and ii, resulting in a decreased formation of precursors of prostaglandins and. Furthermore, we found that administration of mefenamic acid. Mefenamic acid is a white to greyishwhite, odorless, microcrystalline powder with a melting point of 230231c and water solubility of. See what others have said about mefenamic acid, including the effectiveness, ease of use and side effects. Mefenamic acid d3 is a labeled form of mefenamic acid sc205380. Mefenamic acid is a nonsteroidal antiinflammatory drug. Mefenamic acid sc205380 has analgesic and antiinflammatory properties. Mefenamic acid is used shortterm 7 days or less to treat mild to moderate pain in adults and children who are at least.
Estimation and analysis of mefenamic acid suspension. Learn about side effects, warnings, dosage, and more. End of safety data sheet eu einecs list 20051 australia aics. Interaction of mefenamic acid with cobaltii ions in aqueous media. Interaction of mefenamic acid with cobaltii ions in aqueous. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Mefenamic acid cas 61687 scbt santa cruz biotechnology.
Usp, pprc, and biorelevant fasted simulated small intestinal fluid fassif media. Nov 09, 2018 mefenamic acid is a nonsteroidal antiinflammatory drug nsaid. Mefenamic acid is the generic name of the drug, which is the name of the active component that has an effect on your body. Mar 03, 2020 you may also need to avoid mefenamic acid at other times during pregnancy. However, the sds of these drugs have not been investigated using a. Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain pain that happens before or during a menstrual period. Kidney damage can result in blood or pus in the urine, changes in urine chemistry, change in the frequency of urination, insufficiency of kidney function, destruction of the kidney lining and kidney inflammation. Extinguishing media appropriate firefighting equipment. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it is without a warranty of any kind, expressed or implied.
Adverse effects associated with therapeutic use of mefenamic acid include serious gastrointestinal toxicity such as bleeding, ulceration, and perforation and kidney toxicity. Occasionally, the liver may be affected, causing inflammation hepatitis and jaundice. In spite of wide applications of mefenamic acid, the enhancement of its solubility in water using surfactant systems has not been explored. Feb 14, 2017 where can i get more information ponstel. Mefenamic acid enhances anticancer drug sensitivity via inhibition. Pdf in vitro dissolution studies on solid dispersions of mefenamic. Treatment of primary dysmenorrhoea inflammation and fever soft tissue and dental pain. It is also used to relieve pain and cramps during menstrual periods. Mefenamic acid inhibits the activity of the enzymes cyclooxygenase i and ii, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. It works by stopping the bodys production of a substance that causes pain, fever, and inflammation. The following conditions are contraindicated with this drug. The concentration of mefenamic acid is determined using the previously prepared calibration curve using standard solution of mefenamic acid in dioxane.
Chemical and physical properties of mefenamic acid. Know mefenamic acid 250 mg tablet uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug. Evaluation via classic and response surface methods mohammad edrissi2, nima razzaghi asl1. See actual entry in rtecs for complete information. Mefenamic acid oral capsule is a prescription drug used to treat mild to moderate pain and dysmenorrhea menstrual pain. Safety data sheet mefenamic acid according to regulation ec no 19072006, annex ii, as amended. Pharmaceutical product for the treatment of menstrual pain details of the supplier of the safety data sheet 2.
Mefenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3dimethylphenyl group. Mefenamic acid investigated as a drug and reproductive effector, and tumorigen. In patients with renal or hepatic impairment, clearance of metabolites may be decreased. Product identifier product name mefenamic acid product number fm25038. Mefenamic acid is a nonsteroidal antiinflammatory drug nsaid which has demonstrated antiproliferative activity against colorectal cancer cells. You may also know it better by one of its brand names, mefic or ponstan, which are the names given to the medication made by each pharmaceutical company for marketing purposes. Feb 14, 2016 the aim of this research was to study the dissolution profile of mefenamic acid from its solid dosage forms caplet and capsule available in the indonesian market with three different dissolution medium. Enhancement in aqueous solubility of mefenamic acid using. Chemical properties of mefenamic acid cas 61687 download as pdf file download as excel file download as 2d mole file predict properties. Although classed as a nonsteroidal antiinflammatory drug, its antiinflammatory properties are considered to be minor.
N2,3xylyl2aminobenzoic acid n2,3xylylanthranilic acid catalog of chemical suppliers, buyers, custom synthesis companies and equipment manufacturers. Mixture relevant identified uses of the substance or mixture and uses advised against intended use. A quantitative method was developed for the determination of acidic p. Ponstan is indicated for the treatment of primary dysmenorrhoea, dysfunctional uterine bleeding.
Check with your physician if you have any of the following. Our msds database is an easy to use, do it yourself tool, and best of all. Pdf dissolution profile of mefenamic acid solid dosage. P201 obtain special instructions before use p202 do not handle until all safety precautions have been read and understood. Aug 27, 2014 therefore, various methods to improve the dissolution of poorly soluble drugs have been reported and employing surfactants for this purpose is the leading approach. Each bluebanded, ivory capsule contains 250 mg of mefenamic acid for oral administration. First order dissolution plots of mefenamic acid and its solid dispersions. The waste framework directive aims to protect the environment and human health from the generation and management of waste and to. The empirical formula of mefenamic acid is c 15 h 15 no 2, and its formula weight is calculated to be 241. Mefenamic acid is an anthranilic acid and nonsteroidal antiinflammatory drug nsaid with antiinflammatory, antipyretic and analgesic activities.
Mefenamic acid ingestion, usually in excess and over prolonged period is known to produce interstitial nephritis, or less commonly papillary necrosis, with acute renal failure 1. In one small, randomized trial, the prevalence of preterm labor was significantly reduced by mefenamic acid compared with placebo. Extreme high moderate low section 1 chemical product and company identification product name mefenamic acid statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Only select registry of toxic effects of chemical substances rtecs data is presented here. Dizziness, headaches, anemia, increased bleeding time, rashes, and liver effects have also been reported. The diffusivity of water is lower in the binary mixture than in. Mefenamic acid is a nonsteroidal agent with antiinflammatory, analgesic and antipyretic action. The bioavailability and pharmacokinetics of mefenamic acid. Indication of any immediate medical attention and special treatment needed see section 4. Mefenamic acid concentrations reached during therapy have produced in vivo effects. Dissolution profile of mefenamic acid solid dosage forms in. Halflife 5 times longer in preterm infants compared with adults.
Sigmaaldrich offers a number of mefenamic acid products. Ponstan capsules contain the active ingredient mefenamic acid 250 mgcapsule. Pharmaceutical product used as nonsteroidal, antiinflammatory drug nsaid. Mefenamic acid is an nsaid, nsaids treat the symptoms of pain and inflammation.
May 25, 2016 mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro. Mefenamic acid tablets msds material safety data sheet. Pdf solid dispersions of mefanamic acid with a watersoluble polymer. Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells. Request pdf enhancing solubility and dissolution of mefenamic acid by freeze drying mefenamic acid, an antiinflammatory drug, exhibits poor water. Ponstel mefenamic acid side effects, images, uses, dosage. Mefenamic acid is in a class of medications called nsaids. Mefenamic acid 250 mg tablet is a nonsteroidal antiinflammatory nsaid medicine used to treat pain associated with conditions like gout, rheumatoid arthritis, sprains of muscles and joints etc. Mefenamic acid is rapidly absorbed after oral administration. Commission regulation eu no 2015830 of 28 may 2015.
Pdf molecular recognition and solubility of mefenamic acid. They do not treat the disease that causes those symptoms. A spectrophotometric method of assay of mefenamic acid in tablets involving, dissolving the tablet powder in 1,4dioxane and measuring the absorbance at 353. Weve included the most sought after safety data sheets, and the database just keeps growing. Tolfenamic acid investigated as a drug and reproductive effector. Mefenamic acid side effects, dosage, interactions drugs. Hazard identification material safety data sheet material mefenamic acid capsules usp, 250 mg. The bioavailability and pharmacokinetics of mefenamic acid in alloxandiabetic rabbits article pdf available in the tokai journal of experimental and clinical medicine 224. Mefenamic acid is a member of the anthranilic acid derivatives or fenamate class of nsaid drugs, and is used to treat mild to moderate pain, including menstrual pain, and is sometimes used to prevent migraines associated with menstruation. Determination of nonsteroidal antiinflammatory drugs, caffeine.
Talk with your doctor to see when you need to avoid taking mefenamic acid during pregnancy. Pdf molecular recognition and solubility of mefenamic. Mefenamic acid works by reducing hormones that cause inflammation and pain in the body. There are no adequate reports or wellcontrolled studies of mefenamic acid in pregnant women. Naveed s, qamar f, abbas ss, safdar s, ameer s, et al.
Toxic hazardous substances and environmental engineering. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Mefenamic acid 250 mg tablet uses, dosage, side effects. Aug 20, 2019 mefenamic acid oral capsule is a prescription drug used to treat mild to moderate pain and dysmenorrhea menstrual pain. Mefenamic acid is typically prescribed for oral administration. This is not a list of all drugs or health problems that interact with mefenamic acid. Present eu einecs list 2005592 lactose mefenamic acid australia aics. Aug 03, 2015 mefenamic acid tablets special notice. Sigma chemical co mefenamic acid, m4267 650500n093128 product identification product id. Mefenamic acid decreases inflammation and uterine contractions by a stillunknown mechanism. In addition, the use of paracetamol acetaminophen was hampered by fears of. Ponstel mefenamic acid is a member of the fenamate group of nonsteroidal antiinflammatory drugs nsaids. Enhancing solubility and dissolution of mefenamic acid by freeze. Spectrophotometric assay of mefenamic acid in tablets using 1.
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